Across TCGA cell cohorts, WDR5 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WDR5-associated genes across cancer lineages are PRMT8, KRTAP5-6, and PRAMEF14. Each is linked with WDR5 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR5-to-partner and partner-to-WDR5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR5→partner) and Y-score (partner→WDR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRMT8 →	+0.573	+4.409	<.001	.005	3	1
BLOOD_Leukemia	KRTAP5-6 →	+0.312	+4.874	<.001	.002	3	1
LUNG_NSCLC_LUAD	PRAMEF14 →	+0.012	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	CXorf51B →	+2.602	+5.228	<.001	.005	3	1
LARGE_INTESTINE	USP17L7 →	+0.083	+3.691	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

WDR5 survival (RNA) · tumor vs normal (RNA) · all WDR5 data types