WDR49

Across TCGA patient cohorts, WDR49 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR49-associated genes across cancer lineages are TTF1, PCNA, and Caspase-7-cleavedD198. Each is linked with WDR49 in more than 3 cancer types. Because this analysis shows association rather than direction, both WDR49-to-partner and partner-to-WDR49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTF1 grouped by WDR49-low versus WDR49-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR49→partner) and Y-score (partner→WDR49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TTF1 →	+0.390	+3.169	.022	.017	3	4
STAD	PCNA →	+0.243	+2.321	.023	.005	3	3
STAD	Caspase-7-cleavedD198 →	+0.630	+2.459	.022	.018	3	3
STAD	4E-BP1 →	+0.311	+2.321	.005	.005	3	3
STAD	EGFR_pY1068 →	-0.286	-3.149	.046	.017	3	2
UCEC	eIF4E →	+0.164	+3.472	.013	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

TTF1 by WDR49 expression — STAD

Explore this box plot interactively →