Across TCGA patient cohorts, WDR46 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR46-associated genes across cancer lineages are MSH2, TFRC, and Caspase-7-cleavedD198. Each is linked with WDR46 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR46-to-partner and partner-to-WDR46 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR46→partner) and Y-score (partner→WDR46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.197	-2.295	.019	.033	3	2
UCEC	TFRC →	+0.563	+3.459	.003	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.753	+3.019	<.001	<.001	3	2
UCEC	C-Raf →	+0.175	+1.847	<.001	.008	3	2
BLCA	A-Raf_pS299 →	+0.220	+3.000	.010	.036	3	1
BLCA	Dvl3 →	-0.244	-3.000	.047	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration

WDR46 survival (RNA) · tumor vs normal (RNA) · all WDR46 data types