Across TCGA pan-cancer cohorts, WDR45 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated WDR45 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher WDR45 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated WDR45 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, UCEC, and LSCC are the cancer types where WDR45 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	II,III,IV	0.867	0.608	.002	22	view →
UCEC	DFS	Quartile	II,III,IV	0.681	1.000	.027	6	view →
LSCC	DFS	Tertile	All	0.947	1.000	.021	4	view →
PDAC	OS	Quartile	III,IV	0.572	0.896	.016	4	view →
GBM	OS	Median	All	0.432	0.628	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: WDR45 tumor-vs-normal RNA expression · all WDR45 data types