Across TCGA patient cohorts, WDR45 protein abundance is significantly associated with the RNA expression of many other genes, with 4,210 significant associations in total. GBM shows the largest number of these associations.

The most reproducible WDR45-associated genes across cancer lineages are FFAR2, VSIG4, and HHIPL1. Each is linked with WDR45 in more than 2 cancer types. Because this analysis shows association rather than direction, both WDR45-to-partner and partner-to-WDR45 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR45→partner) and Y-score (partner→WDR45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	FFAR2 →	+0.943	+0.339	<.001	.004	3	3
OV	VSIG4 →	+1.309	+0.501	.003	<.001	3	3
GBM	HHIPL1 →	+0.738	+0.216	<.001	<.001	3	3
LSCC	KIAA1671 →	-0.626	-0.167	.003	<.001	3	3
LSCC	MAPK6P3 →	-0.579	-0.227	.005	.001	3	3
PDAC	MEFV →	+0.542	+0.343	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,210 associations by consensus.

Exploration

WDR45 survival (RNA) · tumor vs normal (RNA) · all WDR45 data types