Across TCGA patient cohorts, WDR45 protein abundance is significantly associated with the protein abundance of many other proteins, with 13,139 significant associations in total. GBM shows the largest number of these associations.

The most reproducible WDR45-associated proteins across cancer lineages are ATG2B, HNRNPU, and PRKDC. Each is linked with WDR45 in more than 5 cancer types. Because this analysis shows association rather than direction, both WDR45-to-partner and partner-to-WDR45 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR45→partner) and Y-score (partner→WDR45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ATG2B →	+0.242	+0.332	<.001	<.001	3	6
PDAC	HNRNPU →	-0.180	-0.320	<.001	<.001	3	5
BRCA	PRKDC →	-0.257	-0.179	<.001	<.001	3	4
GBM	RRP15 →	-0.386	-0.184	<.001	<.001	3	4
GBM	SF3B1 →	-0.215	-0.186	.002	<.001	3	4
BRCA	MGA_S534 →	-0.869	-0.177	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,139 associations by consensus.

Exploration

WDR45 survival (RNA) · tumor vs normal (RNA) · all WDR45 data types