WDR45

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, WDR45 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR45-associated genes across cancer lineages are Cyclin-B1, MEK1, and p38-MAPK_pT180_Y182. Each is linked with WDR45 in more than 2 cancer types. Because this analysis shows association rather than direction, both WDR45-to-partner and partner-to-WDR45 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR45→partner) and Y-score (partner→WDR45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCyclin-B1 →+0.514+1.807.007.00433
UCECMEK1 →+0.470+2.523<.001<.00132
UCECp38-MAPK_pT180_Y182 →-0.396-1.234.009.04532
UCECATM →-0.356-1.247.021.04532
COADGSK-3_pS9 →+0.455+2.815.034.03631
UCECEGFR_pY1068 →-0.232-3.321.006.00931
Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration