WDR44

Across TCGA patient cohorts, WDR44 mutation is significantly associated with the RNA expression of many other genes, with 4,519 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR44-associated genes across cancer lineages are VENTXP8, MRPL17, and EOGT. Each is linked with WDR44 in more than 2 cancer types. Because this analysis shows association rather than direction, both WDR44-to-partner and partner-to-WDR44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VENTXP8 grouped by WDR44-low versus WDR44-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR44→partner) and Y-score (partner→WDR44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	VENTXP8 →	+0.235	+3.163	<.001	.007	3	3
UCEC	MRPL17 →	+0.238	+1.828	.002	.002	3	3
UCEC	EOGT →	+0.340	+2.102	.004	<.001	3	3
UCEC	STT3B →	+0.372	+1.606	.002	.002	3	3
UCEC	PATL1 →	+0.306	+1.405	.006	<.001	3	3
UCEC	MTMR10 →	+0.303	+1.684	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,519 associations by consensus.

VENTXP8 by WDR44 expression — HNSC

Explore this box plot interactively →