WDR44

Across TCGA cell cohorts, WDR44 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WDR44-associated genes across cancer lineages are OR1L6, CBLN4, and DEFB125. Each is linked with WDR44 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR44-to-partner and partner-to-WDR44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L6 grouped by WDR44-low versus WDR44-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR44→partner) and Y-score (partner→WDR44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	OR1L6 →	+0.015	+4.169	<.001	.008	3	2
BLOOD_Leukemia	CBLN4 →	+0.004	+4.539	<.001	.007	3	2
BONE	DEFB125 →	+0.029	+4.672	.003	.001	3	1
BONE	GAST →	+0.119	+4.000	.008	.008	3	1
BONE	C2orf80 →	+0.095	+4.169	<.001	.008	3	1
BONE	C1orf68 →	+0.020	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

OR1L6 by WDR44 expression — BONE

Explore this box plot interactively →