WDR43

Across TCGA patient cohorts, WDR43 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR43-associated genes across cancer lineages are eIF4E, MEK1, and ASNS. Each is linked with WDR43 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR43-to-partner and partner-to-WDR43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by WDR43-low versus WDR43-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR43→partner) and Y-score (partner→WDR43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.167	+1.847	.030	.008	3	2
UCEC	MEK1 →	+0.408	+2.415	.002	.003	3	2
UCEC	ASNS →	+0.335	+1.700	.011	.042	3	2
UCEC	EGFR_pY1068 →	-0.215	-1.847	.019	.008	3	1
UCEC	FASN →	+0.388	+2.000	.007	.029	3	1
UCEC	FOXO3a_pS318_S321 →	-0.117	-1.896	.010	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eIF4E by WDR43 expression — UCEC

Explore this box plot interactively →