WDR43

Across TCGA cell cohorts, WDR43 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,005 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible WDR43-associated GO terms across cancer lineages are Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA 5'-end processing, and Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with WDR43 in more than 18 cancer types. Because this analysis shows association rather than direction, both WDR43-to-partner and partner-to-WDR43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by WDR43-low versus WDR43-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR43→partner) and Y-score (partner→WDR43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.197	+0.955	<.001	<.001	3	19
BONE	rRNA 5'-end processing →	+0.197	+0.955	<.001	<.001	3	19
BONE	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.174	+0.955	<.001	<.001	3	19
LARGE_INTESTINE	Transcription by RNA polymerase I →	+0.129	+0.877	<.001	<.001	3	19
BREAST	tRNA wobble guanine modification →	+0.144	+0.721	<.001	<.001	3	18
URINARY_TRACT	Nucleolar large rRNA transcription by RNA polymerase I →	+0.152	+0.923	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,005 associations by consensus.

Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by WDR43 expression — BONE

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