WDR4

Across TCGA pan-cancer cohorts, WDR4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated WDR4 data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher WDR4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated WDR4 expression acts as an unfavorable survival marker, although some lineages such as COAD show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where WDR4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.705	0.948	.002	37	view →
CCRCC	DFS	Median	III,IV	0.523	0.910	.002	26	view →
HNSC	DFS	Median	III,IV	0.900	1.000	.003	12	view →
COAD	DFS	Median	II,III,IV	1.000	0.937	.048	6	view →
LSCC	OS	Tertile	III,IV	0.526	0.943	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

WDR4–PDAC (OS)

Open the PDAC breakdown →