WDR4

Across TCGA patient cohorts, WDR4 mutation is significantly associated with the RNA expression of many other genes, with 2,434 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR4-associated genes across cancer lineages are FADS1, EI24, and ZDHHC7. Each is linked with WDR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR4-to-partner and partner-to-WDR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FADS1 grouped by WDR4-low versus WDR4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR4→partner) and Y-score (partner→WDR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FADS1 →	+0.756	+2.736	<.001	<.001	3	2
UCEC	EI24 →	+0.527	+2.736	<.001	<.001	3	2
UCEC	ZDHHC7 →	+0.417	+2.930	.001	<.001	3	2
UCEC	BOLA3 →	+0.385	+2.855	.003	.001	3	2
UCEC	FAM204A →	+0.400	+3.939	.007	<.001	3	2
UCEC	CDT1 →	+0.728	+3.606	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,434 associations by consensus.

FADS1 by WDR4 expression — UCEC

Explore this box plot interactively →