WDR4

Across TCGA patient cohorts, WDR4 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR4-associated genes across cancer lineages are Bad_pS112, EGFR_pY1068, and eIF4E. Each is linked with WDR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR4-to-partner and partner-to-WDR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bad_pS112 grouped by WDR4-low versus WDR4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR4→partner) and Y-score (partner→WDR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bad_pS112 →	-0.185	-1.861	.014	.049	3	2
UCEC	EGFR_pY1068 →	-0.239	-1.906	.018	.016	3	1
UCEC	eIF4E →	+0.190	+3.183	.025	.009	3	1
UCEC	FOXO3a_pS318_S321 →	-0.100	-1.906	.046	.016	3	1
UCEC	GSK-3_pS9 →	-0.471	-3.321	.003	.009	3	1
UCEC	Ku80 →	+0.288	+2.916	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Bad_pS112 by WDR4 expression — UCEC

Explore this box plot interactively →