WDR4

Across TCGA cell cohorts, WDR4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,801 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible WDR4-associated GO terms across cancer lineages are RNA (guanine-N7)-methylation, IMP biosynthetic process, and rRNA processing. Each is linked with WDR4 in more than 17 cancer types. Because this analysis shows association rather than direction, both WDR4-to-partner and partner-to-WDR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA (guanine-N7)-methylation grouped by WDR4-low versus WDR4-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR4→partner) and Y-score (partner→WDR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RNA (guanine-N7)-methylation →	+0.154	+1.174	<.001	<.001	3	18
BONE	IMP biosynthetic process →	+0.189	+1.314	<.001	<.001	3	17
BLOOD_Myeloma	rRNA processing →	+0.128	+1.441	<.001	<.001	3	17
BLOOD_Myeloma	rRNA metabolic process →	+0.124	+1.615	<.001	<.001	3	17
BONE	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.156	+1.314	<.001	<.001	2	17
BONE	Ribosomal large subunit biogenesis →	+0.144	+1.505	.002	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,801 associations by consensus.

RNA (guanine-N7)-methylation by WDR4 expression — SKIN

Explore this box plot interactively →