WDR4

Across TCGA cell cohorts, WDR4 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible WDR4-associated genes across cancer lineages are KRT85, PPDPFL, and C10orf53. Each is linked with WDR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR4-to-partner and partner-to-WDR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT85 grouped by WDR4-low versus WDR4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR4→partner) and Y-score (partner→WDR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRT85 →	+0.446	+3.823	<.001	.006	3	1
LARGE_INTESTINE	PPDPFL →	+0.040	+3.632	<.001	.003	3	1
LARGE_INTESTINE	C10orf53 →	+0.016	+3.632	<.001	.003	3	1
SKIN	GGTLC2 →	+0.032	+4.273	<.001	.006	3	1
SKIN	MMP26 →	+0.020	+5.022	<.001	.002	3	1
SKIN	OR1L3 →	+0.030	+6.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

KRT85 by WDR4 expression — LARGE_INTESTINE

Explore this box plot interactively →