WDR35

Across TCGA pan-cancer cohorts, WDR35 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated WDR35 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher WDR35 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated WDR35 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where WDR35 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.121	1.000	.017	23	view →
CCRCC	DFS	Median	All	1.000	0.733	.020	5	view →
LSCC	DFS	Quartile	II,III,IV	0.909	1.000	.022	5	view →
PDAC	DFS	Median	III,IV	0.540	0.211	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

WDR35–HNSC (OS)

Open the HNSC breakdown →