WDR35

Across TCGA patient cohorts, WDR35 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR35-associated genes across cancer lineages are MIG-6, PCNA, and Rad50. Each is linked with WDR35 in more than 2 cancer types. Because this analysis shows association rather than direction, both WDR35-to-partner and partner-to-WDR35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by WDR35-low versus WDR35-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR35→partner) and Y-score (partner→WDR35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIG-6 →	+0.115	+3.059	.024	.017	3	2
UCEC	PCNA →	+0.213	+2.000	.005	.003	3	2
UCEC	Rad50 →	-0.229	-1.362	.007	.037	3	2
UCEC	ASNS →	+0.423	+1.700	<.001	.040	3	2
UCEC	ATM →	-0.598	-2.321	<.001	.005	3	2
UCEC	Cyclin-B1 →	+0.603	+2.807	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

MIG-6 by WDR35 expression — COAD

Explore this box plot interactively →