WDR33

Across TCGA pan-cancer cohorts, WDR33 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated WDR33 data layer compared with 20 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher WDR33 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated WDR33 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.

HNSC, COAD, and UCEC are the cancer types where WDR33 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.860	1.000	.014	16	view →
COAD	DFS	Median	II,III,IV	1.000	0.885	.026	12	view →
UCEC	OS	Tertile	II,III,IV	1.000	0.568	.034	12	view →
PDAC	OS	Median	IV	0.951	0.381	.006	9	view →
LUAD	OS	Median	All	0.911	0.774	.031	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

WDR33–HNSC (DFS)

Open the HNSC breakdown →