WDR3

Across TCGA pan-cancer cohorts, WDR3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated WDR3 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher WDR3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated WDR3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where WDR3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.939	0.506	.006	20	view →
PDAC	OS	Tertile	II,III,IV	0.720	0.929	.003	15	view →
HNSC	DFS	Quartile	IV	0.601	0.863	.031	5	view →
GBM	OS	Quartile	All	0.663	0.518	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

WDR3–LSCC (DFS)

Open the LSCC breakdown →