WDR3

Across TCGA patient cohorts, WDR3 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR3-associated genes across cancer lineages are ERK2, Annexin-1, and ASNS. Each is linked with WDR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR3-to-partner and partner-to-WDR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by WDR3-low versus WDR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR3→partner) and Y-score (partner→WDR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.186	+3.584	.004	.002	3	2
UCEC	Annexin-1 →	+0.573	+2.827	.001	.001	3	2
UCEC	ASNS →	+0.509	+3.700	<.001	.001	3	2
UCEC	ATM →	-0.518	-3.571	<.001	.002	3	2
UCEC	14-3-3_beta →	-0.072	-1.673	.035	.040	3	1
UCEC	EGFR_pY1068 →	-0.232	-2.700	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

ERK2 by WDR3 expression — UCEC

Explore this box plot interactively →