WDR3

Across TCGA cell cohorts, WDR3 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WDR3-associated genes across cancer lineages are SALL3, IFT52, and USP14. Each is linked with WDR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR3-to-partner and partner-to-WDR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SALL3 grouped by WDR3-low versus WDR3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR3→partner) and Y-score (partner→WDR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SALL3 →	+1.013	+3.954	<.001	.005	3	2
LARGE_INTESTINE	IFT52 →	+0.441	+3.169	.003	.009	3	1
LARGE_INTESTINE	USP14 →	+0.570	+3.389	.003	.001	3	1
LARGE_INTESTINE	MRPL51 →	+0.336	+2.265	.008	.001	3	1
LARGE_INTESTINE	ABCD3 →	+0.504	+2.265	.007	.001	3	1
LARGE_INTESTINE	VASP →	-0.525	-3.239	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

SALL3 by WDR3 expression — BLOOD_Lymphoma

Explore this box plot interactively →