WDR26

Across TCGA pan-cancer cohorts, WDR26 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of WDR26’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where WDR26 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WDR26 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

LIHC, BRCA, and KICH are the cancer types where WDR26 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WDR26 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.236	<.001	9	view →
BRCA	All	II,III,IV	+0.551	<.001	6	view →
KICH	All	All	−0.804	<.001	5	view →
LUAD	All	All	+0.299	<.001	5	view →
KIRC	All	All	+0.231	.001	4	view →
CHOL	Male	All	+2.061	<.001	3	view →
KIRP	Female	II,III,IV	+0.885	.040	3	view →
LUSC	All	All	+0.184	.014	2	view →
HNSC	Female	III,IV	+0.433	.034	1	view →
COAD	Male	II,III,IV	+0.200	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

WDR26–LIHC

Open the LIHC breakdown →