WDR20

Across TCGA patient cohorts, WDR20 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR20-associated genes across cancer lineages are Notch1, C-Raf, and eIF4E. Each is linked with WDR20 in more than 2 cancer types. Because this analysis shows association rather than direction, both WDR20-to-partner and partner-to-WDR20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by WDR20-low versus WDR20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR20→partner) and Y-score (partner→WDR20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.214	+3.013	<.001	.018	3	3
UCEC	C-Raf →	+0.190	+3.459	.002	.005	3	3
UCEC	eIF4E →	+0.213	+3.321	.020	.010	3	1
UCEC	ERK2 →	+0.248	+3.321	.003	.009	3	1
UCEC	Ku80 →	+0.336	+2.128	.001	.010	3	1
UCEC	MEK1 →	+0.350	+3.321	.028	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Notch1 by WDR20 expression — UCEC

Explore this box plot interactively →