WDR20

Across TCGA cell cohorts, WDR20 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WDR20-associated genes across cancer lineages are COX6A2, OR1L6, and PRR23B. Each is linked with WDR20 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR20-to-partner and partner-to-WDR20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6A2 grouped by WDR20-low versus WDR20-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR20→partner) and Y-score (partner→WDR20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COX6A2 →	+0.082	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR1L6 →	+0.022	+4.437	<.001	.004	3	1
LARGE_INTESTINE	PRR23B →	+0.005	+4.217	<.001	.001	3	1
BLOOD_Leukemia	IP6K3 →	+0.052	+4.234	<.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

COX6A2 by WDR20 expression — LARGE_INTESTINE

Explore this box plot interactively →