WDR19

Across TCGA pan-cancer cohorts, WDR19 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of WDR19’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where WDR19 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types WDR19 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

LSCC, LUAD, and PDAC are the cancer types where WDR19 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WDR19 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	All	−0.730	<.001	9	view →
LUAD	Female	III,IV	−0.678	<.001	9	view →
PDAC	Female	III,IV	−0.552	<.001	8	view →
HNSC	Male	III,IV	−0.434	<.001	8	view →
CCRCC	All	All	−0.099	<.001	7	view →
OV	All	All	−0.468	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

WDR19–LSCC

Open the LSCC breakdown →