WDR19

Across TCGA cell cohorts, WDR19 mutation is significantly associated with the RNA expression of many other genes, with 246 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WDR19-associated genes across cancer lineages are SIKE1, C20orf173, and TARM1. Each is linked with WDR19 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR19-to-partner and partner-to-WDR19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIKE1 grouped by WDR19-low versus WDR19-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR19→partner) and Y-score (partner→WDR19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SIKE1 →	+0.567	+2.386	.004	.007	3	2
LUNG_NSCLC_LUAD	C20orf173 →	+0.042	+3.977	<.001	.005	3	1
LUNG_NSCLC_LUAD	TARM1 →	+0.019	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	DPEP2NB →	+0.075	+4.558	<.001	.003	3	1
LUNG_NSCLC_LUAD	SCYGR2 →	+0.113	+3.544	<.001	.009	3	1
SKIN	OR52W1 →	+0.043	+3.321	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 246 associations by consensus.

SIKE1 by WDR19 expression — LARGE_INTESTINE

Explore this box plot interactively →