WDR18

Across TCGA pan-cancer cohorts, WDR18 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated WDR18 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher WDR18 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated WDR18 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

UCEC, PDAC, and LSCC are the cancer types where WDR18 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	0.386	1.000	.002	22	view →
PDAC	DFS	Tertile	IV	0.934	0.231	.024	12	view →
LSCC	DFS	Median	II,III,IV	0.840	0.555	.014	8	view →
LUAD	DFS	Quartile	II,III,IV	0.992	0.698	.021	7	view →
GBM	OS	Tertile	All	0.557	0.301	.017	6	view →
CCRCC	DFS	Tertile	All	0.763	0.904	.033	4	view →
HNSC	OS	Quartile	III,IV	0.820	0.510	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

WDR18–UCEC (DFS)

Open the UCEC breakdown →