WDR18

Across TCGA patient cohorts, WDR18 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR18-associated genes across cancer lineages are IGFBP2, Rad50, and Annexin-1. Each is linked with WDR18 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR18-to-partner and partner-to-WDR18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by WDR18-low versus WDR18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR18→partner) and Y-score (partner→WDR18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.927	-3.169	.009	.020	3	1
UCEC	Rad50 →	-0.358	-3.169	.007	.020	3	1
UCEC	Annexin-1 →	+0.665	+2.827	.021	.035	3	1
UCEC	N-Ras →	-0.130	-3.156	.047	.020	2	1
UCEC	TIGAR →	+0.181	+3.196	.031	.010	2	1
UCEC	ATM →	-0.702	-3.169	.004	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

IGFBP2 by WDR18 expression — UCEC

Explore this box plot interactively →