WDPCP

Across TCGA cell cohorts, WDPCP mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible WDPCP-associated genes across cancer lineages are HTR1B, KRTAP4-1, and AFM. Each is linked with WDPCP in more than 1 cancer types. Because this analysis shows association rather than direction, both WDPCP-to-partner and partner-to-WDPCP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTR1B grouped by WDPCP-low versus WDPCP-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDPCP→partner) and Y-score (partner→WDPCP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HTR1B →	+0.101	+4.350	<.001	.005	3	2
BLOOD_Leukemia	KRTAP4-1 →	+0.029	+4.874	<.001	.002	3	2
BLOOD_Leukemia	AFM →	+0.136	+4.276	.001	.007	3	2
LUNG_NSCLC_LUAD	IZUMO3 →	+0.019	+3.362	.001	.007	3	2
BLOOD_Lymphoma	HOXB1 →	+0.014	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	TAS2R7 →	+0.024	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

HTR1B by WDPCP expression — BLOOD_Lymphoma

Explore this box plot interactively →