WDHD1

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, WDHD1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDHD1-associated genes across cancer lineages are 14-3-3_beta, MEK1, and Annexin-1. Each is linked with WDHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDHD1-to-partner and partner-to-WDHD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDHD1→partner) and Y-score (partner→WDHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCEC14-3-3_beta →-0.094-3.295.009.00932
UCECMEK1 →+0.272+1.700.039.04232
UCECAnnexin-1 →+0.443+2.604.019.00532
UCECCaspase-7-cleavedD198 →+0.564+1.720.008.02532
COADNF2 →+0.221+2.815.038.03632
COADC-Raf →+0.238+2.815.002.03632
Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

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