WDFY4

Across TCGA pan-cancer cohorts, WDFY4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated WDFY4 data layer compared with 25 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher WDFY4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated WDFY4 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, CCRCC, and HNSC are the cancer types where WDFY4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.935	0.494	.001	13	view →
CCRCC	DFS	Median	IV	0.220	0.781	.017	13	view →
HNSC	DFS	Median	II,III,IV	0.680	0.897	.003	13	view →
COAD	DFS	Median	III,IV	0.826	1.000	.029	12	view →
PDAC	DFS	Tertile	III,IV	0.979	0.515	.036	3	view →
LSCC	OS	Quartile	II,III,IV	0.633	0.927	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

WDFY4–LUAD (DFS)

Open the LUAD breakdown →