WDFY3

Across TCGA pan-cancer cohorts, WDFY3 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of WDFY3’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where WDFY3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types WDFY3 is over-expressed in tumor, although a few such as LSCC and OV show the opposite, repressed pattern.

LSCC, PDAC, and OV are the cancer types where WDFY3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WDFY3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	−0.340	<.001	9	view →
PDAC	Female	II,III,IV	+0.326	.001	5	view →
OV	All	All	−0.394	.001	2	view →
LUAD	Male	All	−0.095	<.001	2	view →
HNSC	All	All	−0.070	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

WDFY3–LSCC

Open the LSCC breakdown →