WDFY3

Across TCGA patient cohorts, WDFY3 mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDFY3-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and eIF4E. Each is linked with WDFY3 in more than 4 cancer types. Because this analysis shows association rather than direction, both WDFY3-to-partner and partner-to-WDFY3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by WDFY3-low versus WDFY3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDFY3→partner) and Y-score (partner→WDFY3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+1.040	+2.459	<.001	.016	3	5
UCEC	PCNA →	+0.185	+1.292	<.001	<.001	3	5
UCEC	eIF4E →	+0.188	+1.292	<.001	<.001	3	4
LUAD	TFRC →	+0.740	+2.000	<.001	.009	3	3
COAD	eEF2 →	+0.291	+2.906	.004	.001	3	3
STAD	c-Kit →	-0.393	-2.321	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

Caspase-7-cleavedD198 by WDFY3 expression — STAD

Explore this box plot interactively →