WDFY3

Across TCGA cell cohorts, WDFY3 mutation is significantly associated with the RNA expression of many other genes, with 2,517 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WDFY3-associated genes across cancer lineages are ENOPH1, ZBED4, and PPAT. Each is linked with WDFY3 in more than 3 cancer types. Because this analysis shows association rather than direction, both WDFY3-to-partner and partner-to-WDFY3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENOPH1 grouped by WDFY3-low versus WDFY3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDFY3→partner) and Y-score (partner→WDFY3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ENOPH1 →	+0.530	+3.321	<.001	.004	3	4
LARGE_INTESTINE	ZBED4 →	+0.586	+3.584	<.001	<.001	3	4
LARGE_INTESTINE	PPAT →	+0.546	+2.055	.001	<.001	3	4
BLOOD_Leukemia	GNA13 →	+0.600	+3.351	.002	.003	3	3
SKIN	AOC2 →	+0.645	+3.321	<.001	.003	3	3
BLOOD_Leukemia	UBXN4 →	+0.567	+3.411	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,517 associations by consensus.

ENOPH1 by WDFY3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →