WDFY2

Across TCGA patient cohorts, WDFY2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDFY2-associated genes across cancer lineages are ERK2, ETS-1, and GATA3. Each is linked with WDFY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDFY2-to-partner and partner-to-WDFY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by WDFY2-low versus WDFY2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDFY2→partner) and Y-score (partner→WDFY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.295	+3.700	<.001	.001	3	1
UCEC	ETS-1 →	+0.384	+2.906	.004	.001	3	1
UCEC	GATA3 →	+0.191	+3.459	.017	.005	3	1
UCEC	GATA6 →	-0.151	-2.215	.021	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.189	-2.209	.008	.011	3	1
UCEC	JNK2 →	+0.209	+1.700	.013	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ERK2 by WDFY2 expression — UCEC

Explore this box plot interactively →