WDFY2

Across TCGA cell cohorts, WDFY2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WDFY2-associated genes across cancer lineages are KRTAP10-2, BHLHA9, and CENPVL1. Each is linked with WDFY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDFY2-to-partner and partner-to-WDFY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-2 grouped by WDFY2-low versus WDFY2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDFY2→partner) and Y-score (partner→WDFY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRTAP10-2 →	+0.060	+4.257	<.001	<.001	3	2
KIDNEY	BHLHA9 →	+0.036	+5.000	<.001	.005	3	1
LARGE_INTESTINE	CENPVL1 →	+0.127	+2.925	.001	.007	3	1
LUNG_NSCLC_LUAD	SPATA31D1 →	+0.006	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

KRTAP10-2 by WDFY2 expression — LARGE_INTESTINE

Explore this box plot interactively →