WDFY1

Across TCGA pan-cancer cohorts, WDFY1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated WDFY1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher WDFY1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated WDFY1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

COAD, LSCC, and LUAD are the cancer types where WDFY1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	III,IV	0.724	1.000	.007	66	view →
LSCC	OS	Quartile	II,III,IV	0.487	0.931	.004	22	view →
LUAD	DFS	Tertile	II,III,IV	0.866	0.185	.002	18	view →
CCRCC	DFS	Median	All	0.533	0.922	.004	5	view →
PDAC	DFS	Quartile	II,III,IV	0.552	0.203	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

WDFY1–COAD (DFS)

Open the COAD breakdown →