WDFY1

Across TCGA patient cohorts, WDFY1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDFY1-associated genes across cancer lineages are FOXO3a_pS318_S321, IGFBP2, and INPP4B. Each is linked with WDFY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDFY1-to-partner and partner-to-WDFY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by WDFY1-low versus WDFY1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDFY1→partner) and Y-score (partner→WDFY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.122	-2.575	.012	.010	3	1
UCEC	IGFBP2 →	-0.670	-2.000	.008	.010	3	1
UCEC	INPP4B →	-0.287	-2.807	.024	.003	3	1
UCEC	JNK_pT183_Y185 →	-0.158	-1.986	.016	.010	3	1
UCEC	JNK2 →	+0.243	+2.196	.001	.032	3	1
UCEC	p62 Lck ligand →	+0.391	+2.594	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FOXO3a_pS318_S321 by WDFY1 expression — UCEC

Explore this box plot interactively →