WDFY1

Across TCGA cell cohorts, WDFY1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WDFY1-associated genes across cancer lineages are OR6C76, MAGEB10, and PRAMEF20. Each is linked with WDFY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDFY1-to-partner and partner-to-WDFY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6C76 grouped by WDFY1-low versus WDFY1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDFY1→partner) and Y-score (partner→WDFY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR6C76 →	+0.281	+5.029	<.001	.006	3	1
LARGE_INTESTINE	MAGEB10 →	+0.072	+3.345	<.001	.007	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.010	+4.022	<.001	.006	3	1
BLOOD_Leukemia	CALHM4 →	+0.019	+3.684	<.001	.004	3	1
BLOOD_Leukemia	C5orf38 →	+1.358	+3.551	<.001	.008	3	1
BLOOD_Leukemia	CLPSL2 →	+0.242	+3.949	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR6C76 by WDFY1 expression — LUNG_SCLC

Explore this box plot interactively →