Across TCGA pan-cancer cohorts, WBP2P1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of WBP2P1’s most consistent transcriptional readouts.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where WBP2P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types WBP2P1 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
UCEC and LUSC are the cancer types where WBP2P1 tumor–normal differential expression is most reproducible.