WBP2

Across TCGA patient cohorts, WBP2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WBP2-associated genes across cancer lineages are ACC_pS79, ACC1, and IGFBP2. Each is linked with WBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both WBP2-to-partner and partner-to-WBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by WBP2-low versus WBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WBP2→partner) and Y-score (partner→WBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.360	+2.999	.021	.035	3	1
UCEC	ACC1 →	+0.392	+2.700	.016	.006	3	1
UCEC	IGFBP2 →	-0.951	-2.700	.001	.006	3	1
UCEC	Ku80 →	+0.247	+2.179	.020	.034	3	1
UCEC	p90 RSK →	+0.218	+2.013	.011	.018	3	1
UCEC	p62 Lck ligand →	+0.343	+3.807	.019	<.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ACC_pS79 by WBP2 expression — UCEC

Explore this box plot interactively →