WBP11P1

Across TCGA patient cohorts, WBP11P1 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WBP11P1-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and ERK2. Each is linked with WBP11P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WBP11P1-to-partner and partner-to-WBP11P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by WBP11P1-low versus WBP11P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WBP11P1→partner) and Y-score (partner→WBP11P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.280	-2.000	.001	.003	3	2
UCEC	A-Raf_pS299 →	-0.160	-2.392	<.001	<.001	3	2
UCEC	ERK2 →	+0.189	+2.000	.005	.003	3	2
UCEC	FoxM1 →	+0.290	+2.874	.001	<.001	3	2
UCEC	INPP4B →	-0.376	-3.807	<.001	<.001	3	2
UCEC	JNK_pT183_Y185 →	-0.149	-2.115	.012	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

EGFR_pY1068 by WBP11P1 expression — UCEC

Explore this box plot interactively →