WBP1

Across TCGA cell cohorts, WBP1 mutation is significantly associated with the drug of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WBP1-associated genes across cancer lineages are QL-XII-61, JAK3_7406, and Ruxolitinib. Each is linked with WBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WBP1-to-partner and partner-to-WBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, QL-XII-61 grouped by WBP1-low versus WBP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WBP1→partner) and Y-score (partner→WBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	QL-XII-61 →	+0.433	+2.672	.014	.039	3	1
LARGE_INTESTINE	JAK3_7406 →	+0.463	+2.871	.016	.021	3	1
LARGE_INTESTINE	Ruxolitinib →	+0.311	+2.868	.032	.022	3	1
LARGE_INTESTINE	Pevonedistat →	+0.727	+2.871	.025	.021	3	1
LARGE_INTESTINE	BX-912 →	+0.627	+2.874	.022	.021	3	1
LARGE_INTESTINE	GW441756 →	+0.458	+2.807	.004	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

QL-XII-61 by WBP1 expression — LARGE_INTESTINE

Explore this box plot interactively →