WASL

Across TCGA patient cohorts, WASL mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WASL-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and Shc_pY317. Each is linked with WASL in more than 2 cancer types. Because this analysis shows association rather than direction, both WASL-to-partner and partner-to-WASL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by WASL-low versus WASL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WASL→partner) and Y-score (partner→WASL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.101	-1.680	.007	.042	3	2
UCEC	eIF4E →	+0.184	+2.807	.020	.003	3	2
UCEC	Shc_pY317 →	-0.187	-3.807	.001	<.001	3	2
COAD	ATM →	-0.535	-2.991	.008	.036	3	2
UCEC	4E-BP1_pT70 →	+0.092	+2.321	.033	.034	2	3
COAD	c-Jun_pS73 →	-0.175	-2.957	.033	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

14-3-3_beta by WASL expression — UCEC

Explore this box plot interactively →