WASHC5

Across TCGA patient cohorts, WASHC5 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WASHC5-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and Notch1. Each is linked with WASHC5 in more than 3 cancer types. Because this analysis shows association rather than direction, both WASHC5-to-partner and partner-to-WASHC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by WASHC5-low versus WASHC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WASHC5→partner) and Y-score (partner→WASHC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.500	+1.697	.010	.012	3	4
UCEC	MEK1 →	+0.425	+3.807	<.001	<.001	3	2
COAD	Notch1 →	+0.257	+3.178	.004	.010	3	2
UCEC	TFRC →	+0.366	+1.700	.036	.042	3	2
UCEC	ATM →	-0.568	-1.652	<.001	.006	3	2
UCEC	4E-BP1 →	+0.209	+2.837	.019	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Caspase-7-cleavedD198 by WASHC5 expression — UCEC

Explore this box plot interactively →