WASHC4

Across TCGA pan-cancer cohorts, WASHC4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated WASHC4 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher WASHC4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated WASHC4 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where WASHC4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.704	0.874	.001	40	view →
LUAD	DFS	Quartile	III,IV	1.000	0.200	.008	12	view →
HNSC	DFS	Tertile	II,III,IV	0.987	0.901	.023	5	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

WASHC4–PDAC (DFS)

Open the PDAC breakdown →