WASHC4

Across TCGA patient cohorts, WASHC4 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WASHC4-associated genes across cancer lineages are Fibronectin, MEK1, and mTOR_pS2448. Each is linked with WASHC4 in more than 3 cancer types. Because this analysis shows association rather than direction, both WASHC4-to-partner and partner-to-WASHC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by WASHC4-low versus WASHC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WASHC4→partner) and Y-score (partner→WASHC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.202	-1.238	.048	.041	3	4
UCEC	MEK1 →	+0.409	+2.485	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.104	-1.420	.024	.022	3	2
UCEC	Notch1 →	+0.139	+1.512	.001	.017	3	2
UCEC	Rab25 →	-0.326	-1.925	.001	.004	3	2
UCEC	Rictor_pT1135 →	-0.087	-1.362	.006	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Fibronectin by WASHC4 expression — UCEC

Explore this box plot interactively →