WASHC4

Across TCGA cell cohorts, WASHC4 mutation is significantly associated with the RNA expression of many other genes, with 737 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WASHC4-associated genes across cancer lineages are C20orf85, TEX46, and EPPIN. Each is linked with WASHC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both WASHC4-to-partner and partner-to-WASHC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by WASHC4-low versus WASHC4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WASHC4→partner) and Y-score (partner→WASHC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf85 →	+0.027	+3.969	<.001	.009	3	2
LARGE_INTESTINE	TEX46 →	+0.120	+2.497	<.001	.001	3	2
BLOOD_Lymphoma	EPPIN →	+0.041	+3.714	<.001	.006	3	1
BLOOD_Lymphoma	HOXB1 →	+0.011	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	TAS2R7 →	+0.019	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	DEFB129 →	+0.026	+4.662	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 737 associations by consensus.

C20orf85 by WASHC4 expression — BLOOD_Leukemia

Explore this box plot interactively →