WASHC3

Across TCGA patient cohorts, WASHC3 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WASHC3-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, JNK2, and MEK1. Each is linked with WASHC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both WASHC3-to-partner and partner-to-WASHC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by WASHC3-low versus WASHC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WASHC3→partner) and Y-score (partner→WASHC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.587	+2.817	.027	.036	3	1
UCEC	JNK2 →	+0.349	+3.009	<.001	.019	3	1
UCEC	MEK1 →	+0.457	+3.000	.017	.036	3	1
UCEC	Mre11 →	-0.114	-2.970	.011	.036	3	1
UCEC	PEA-15_pS116 →	+0.508	+3.321	.005	.010	3	1
UCEC	Tuberin →	+0.374	+2.179	.008	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Acetyl-a-Tubulin-Lys40 by WASHC3 expression — UCEC

Explore this box plot interactively →